Limitations of Antinuclear Antibody Tests (HEp-2) Are Overcome with the Autoimmune Target Test (IT-1) in Systemic Lupus Erythematosus
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چکیده
منابع مشابه
Antinuclear antibody-negative systemic lupus erythematosus - how common?
A review of five years' DNA-binding antibody results in a routine service laboratory revealed 38 patients who had high DNA-binding capacity (DNA-bc) but no antinuclear antibodies (ANA). On retrospective case note analysis, 22 patients (58%) were thought to have systemic lupus erythematosus (SLE), although only six (16%) fulfilled the preliminary classification criteria of the American Rheumatis...
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Autoantibodies to the three extractable nuclear antigens (ENA), Anti-SSA (Ro), Anti-Sm, Anti-RNP and antinuclear antibodies were determined in 150 patients with SLE. Seventy patients (46.7%) had Anti-SSA (Ro), 40 (26.7%) Anti-Sm and 25 (16.7%) Anti-RNP antibodies. Ninety four percent patients had a positive Fluorescent anti-nuclear antibody (FANA) test. The commonest FANA pattern is the speckle...
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Background: Brucellosis is a zoonotic infection which is endemic in many countries. It is a multisystem disease which may present with a broad spectrum of clinical manifestations and complications. Neurobrucellosis is an uncommon complication of brucellosis. Case presentation: A 25-year-old woman with a history of lupus for 5 months referred to the emergency ward of Shahid Beheshti Hosp...
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Introduction Autoimmune hepatits (AIH) is characterized by increased liver enzymes, hypergammaglobulinemia, specific autoantibodies and typical hystologic findings. Extrahepatic autoimmune phenomena may coexist with type 1 AIH. Systemic lupus erythematosus (SLE) is a chronic multisystem autoimmune disease associated with the production of autoantibodies. Although it has the potential to affect ...
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Background: In lupus nephritis (LN), deposition of pathogenic autoantibodies in the glomeruli is mediated via cross-reactivity with alpha-actinin. Association of serum alpha-actinin antibody (AαA) with LN has been shown in a few studies but the results are controversial. Methods: Eighty patients into entered the study. The diagnosis of SLE was confirmed according to the American College of Rheu...
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ژورنال
عنوان ژورنال: The Journal of Rheumatology
سال: 2009
ISSN: 0315-162X,1499-2752
DOI: 10.3899/jrheum.090118